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Article

Relation of the Allelic Variants of Multidrug Resistance Gene to Agranulocytosis Associated With Clozapine.

Journal of clinical psychopharmacology - 1 Jun 2016

Anıl Yağcioğlu A Elif, Yoca Gökhan, Ayhan Yavuz, Karaca R Özgür, Çevik Lokman, Müderrisoğlu Ahmet, Göktaş Mustafa T, Eni Nurhayat, Yazıcı M Kâzım, Bozkurt Atilla, Babaoğlu Melih O

Abstract excerpt

Clozapine use is associated with leukopenia and more rarely agranulocytosis, which may be lethal. The drug and its metabolites are proposed to interact with the multidrug resistance transporter (ABCB1/MDR1) gene product, P-glycoprotein (P-gp). Among various P-glycoprotein genetic polymorphisms, nucleotide changes in exons 26 (C3435T), 21 (G2677T), and 12 (C1236T) have been implicated for changes in...

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Identifiers

PMID: 27043126
DOI: 10.1097/JCP.0000000000000495

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ABCB1

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