Article
Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms?
Journal of clinical psychopharmacology - 1 Oct 2005
Mosyagin Igor, Cascorbi Ingolf, Schaub Rainer, Krüger Timo, Dettling Michael
Abstract excerpt
Drug-induced agranulocytosis is a rare but life-threatening side effect which is possibly based on immunogenetic mechanisms. Some studies regarding agranulocytosis induced by the atypical antipsychotic clozapine dealing with HLA subtyping and enzyme polymorphisms have been performed to elucidate its genetic background. To further screen possibly genetically based pathways of developing agranulocytosis, we...
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