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Article

Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature.

Lung cancer (Amsterdam, Netherlands) - 1 May 2016

Siegele Bradford J, Shilo Konstantin, Chao Bo H, Carbone David P, Zhao Weiqiang, Ioffe Olga, Franklin Wilbur A, Edelman Martin J, Aisner Dara L

Abstract excerpt

Activating mutations in the epidermal growth factor receptor (EGFR) gene are exceedingly rare in small cell lung cancer (SCLC). We present two cases of SCLC harboring EGFR mutations, one in an 82 year-old male smoker with a combined SCLC and adenocarcinoma with a novel D855H point mutation in exon 21, and the second in a 68 year-old female never smoker with the L858R point mutation in exon 21. The cases,...

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Identifiers

PMID: 27040854
DOI: 10.1016/j.lungcan.2016.02.012
PMCID: PMC5524560

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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