Article
Uncommon EGFR mutations in advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Jul 2017
O'Kane Grainne M, Bradbury Penelope A, Feld Ronald, Leighl Natasha B, Liu Geoffrey, Pisters Katherine-M, Kamel-Reid Suzanne, Tsao Ming S, Shepherd Frances A
Abstract excerpt
Molecular profiling in advanced non-small cell lung cancer (NSCLC) has allowed for the detection of actionable mutations, which has revolutionized the treatment paradigm in this highly fatal disease. Mutations involving the epidermal growth factor receptor (EGFR) gene are most common and the 'classical mutations', exon 19 deletions and the point mutation L858R at exon 21, predict response to EGFR tyrosine kinase...
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