Article
Rare mutations in non-small-cell lung cancer.
Future oncology (London, England) - 1 May 2013
D'Arcangelo Manolo, D'Incecco Armida, Cappuzzo Federico
Abstract excerpt
In the last decade, new insights in molecular biology have changed the therapeutic landscape of non-small-cell lung cancer. Since 2004, when activating mutations of the EGFR were firstly identified, several genetic aberrations have been discovered, mainly in adenocarcinoma. EGFR mutations are a relatively frequent event in non-small-cell lung cancer, generally consisting of exon 19 deletion or exon 21...
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