Article
Uncommon mutations in epidermal growth factor receptor and response to first and second generation tyrosine kinase inhibitors: A case series and literature review.
Lung cancer (Amsterdam, Netherlands) - 1 Jan 2018
Galli Giulia, Corrao Giulia, Imbimbo Martina, Proto Claudia, Signorelli Diego, Ganzinelli Monica, Zilembo Nicoletta, Vitali Milena, de Braud Filippo, Garassino Marina Chiara, Lo Russo Giuseppe
Abstract excerpt
Epidermal growth factor receptor (EGFR) is the most common driver gene involved in non small cell lung cancer (NSCLC) growth, being found in approximately 10-15% of Caucasian and 40% of Asian patients. A wide variety of pathogenic mutations, deletions, insertions and duplications have been described in EGFR exons 18-21. The presence of the most common among them (e.g. exon 21 L851R and exon 19 deletions) is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.