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Article

Development of Unlabeled Probe Based High-Resolution Melting Analysis for Detection of Filaggrin Gene Mutation c.3321delA.

Journal of clinical laboratory analysis - 1 Nov 2016

Zhong Wei-Long, Wang Luo, Wu Xia, Zhang Jie, Chen Xiao-Fan, Zhang Wei, Dou Xia, Yu Bo

Abstract excerpt

BACKGROUND: Filaggrin gene (FLG) plays an important role in skin barrier function, and loss-of-function mutations of FLG have been shown to be a predisposing factor for atopic dermatitis (AD). The c.3321delA mutation is the most common FLG mutation in Chinese population. We aim to develop a rapid, cost-efficiency, and reliable closed-tube method that has not been described for the detection of c.3321delA...

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Identifiers

PMID: 27040325
DOI: 10.1002/jcla.21953
PMCID: PMC6806714

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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