Article
Peptide nucleic acid (PNA) probe-based analysis to detect filaggrin mutations in atopic dermatitis patients.
Experimental dermatology - 1 Nov 2018
Hwang Joonsung, Lee Sangku, Kim Daehwan, Han Goeun, Soung Nak Kyun, Cha-Molstad Hyunjoo, Lee Kyung Ho, Ryoo In Ja, Ahn Mi Ja, Kim Sung Tae, Lee Min Jae, Yoo Young Dong, Lee Hee Gu, Hong Jin Tae, Kim Hyunjung, Choi Eung Ho, Kim Soo-Chan, Kwon Yong Tae, Ahn Jong Seog, Kim Bo Yeon
Abstract excerpt
Atopic dermatitis (AD) is a chronic inflammatory skin disease whose prevalence is increasing worldwide. Filaggrin (FLG) is essential for the development of the skin barrier, and its genetic mutations are major predisposing factors for AD. In this study, we developed a convenient and practical method to detect FLG mutations in AD patients using peptide nucleic acid (PNA) probes labelled with fluorescent markers...
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