Article
Filaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population.
PloS one - 1 Jan 2014
Meng Li, Wang Li, Tang Huayang, Tang Xianfa, Jiang Xiaoyun, Zhao Jinhua, Gao Jing, Li Bing, Fu Xuhui, Chen Yan, Yao Weiyi, Zhan Wenying, Wu Bo, Duan Dawei, Shen Changbing, Cheng Hui, Zuo Xianbo, Yang Sen, Sun Liangdan, Zhang Xuejun
Abstract excerpt
BACKGROUND: We confirmed that the filaggrin gene mutation c.3321delA is associated with atopic dermatitis in our previous genome wide association study of the Chinese Han population. c.3321delA is the most common filaggrin gene mutation in Chinese atopic dermatitis patients but is not present in European populations. OBJECTIVE: To investigate the genetic model for the c.3321delA mutation and to determine the...
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