Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients.

doi:10.7314/apjcp.2016.17.3.1175

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Article

Distribution of KRAS and BRAF Mutations in Metastatic Colorectal Cancers in Turkish Patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016

Gorukmez Orhan, Yakut Tahsin, Gorukmez Ozlem, Sag Sebnem Ozemri, Karkucak Mutlu, Kanat Ozkan

Abstract excerpt

The results of this study demonstrate the potential prognostic and predictive values of KRAS and BRAF gene mutations in patients with colorectal cancer (CRC). It has been proven that KRAS and BRAF mutations are predictive biomarkers for resistance to anti-EGFR monoclonal antibody treatment in patients with metastatic CRC (mCRC). We demonstrated the distribution of KRAS (codons 12, 13 and 61) and BRAF (codon 600)...

Topics

Adenocarcinoma, Mucinous
Adult
Aged
Biomarkers, Tumor
Colorectal Neoplasms
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Staging

Prognosis

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Retrospective Studies

Survival Rate

Source

Open in PubMed

Identifiers

PMID: 27039744
DOI: 10.7314/apjcp.2016.17.3.1175

Genes

KRAS
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27039744-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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