Article
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma.
European journal of cancer (Oxford, England : 1990) - 1 Jun 2016
Workel Hagma H, Komdeur Fenne L, Wouters Maartje C A, Plat Annechien, Klip Harry G, Eggink Florine A, Wisman G Bea A, Arts Henriette J G, Oonk Maaike H M, Mourits Marian J E, Yigit Refika, Versluis Marco, Duiker Evelien W, Hollema Harry, de Bruyn Marco, Nijman Hans W
Abstract excerpt
INTRODUCTION: Intraepithelial CD8+ tumour-infiltrating T-lymphocytes (TIL) are associated with a prolonged survival in endometrial cancer (EC). By contrast, stromal infiltration of CD8+ TIL does not confer prognostic benefit. A single marker to discriminate these populations would therefore be of interest for rapid assessment of the tumour immune contexture, ex vivo analysis of intraepithelial and stromal T-cells...
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