Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased CD103-CD8+ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC.

Cancer immunology, immunotherapy : CII - 3 Nov 2025

Liu Jinsheng, Zeng Jintao, Zhou Ting, Wu Mi, Weng Xiufang

Abstract excerpt

While mismatch repair-deficient (dMMR) colorectal cancers (CRCs) exhibit strong immunogenicity and better response to immune checkpoint inhibitors, the more prevalent mismatch repair-proficient (pMMR) CRCs typically show poor T- cell infiltration and inferior outcomes. Profiling the limited tumor-infiltrating CD8+ T cells helps identify responders and guides new strategies to enhance their infiltration and...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
CD8-Positive T-Lymphocytes
DNA Mismatch Repair
Lymphocytes, Tumor-Infiltrating
Antigens, CD

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Integrin alpha Chains

Female

Male

Phenotype

Prognosis

Middle Aged

Tumor Microenvironment

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41182407
DOI: 10.1007/s00262-025-04214-w
PMCID: PMC12583254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased CD103-CD8+ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC.PMID 41182407Read ↗

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumoursSemantic proximity Read ↗

Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient’s survival and immunotherapy responsivenessSemantic proximity Read ↗

Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgerySemantic proximity Read ↗

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.Semantic proximity Read ↗

Phenotypic Differences of CD103+ Tissue-Resident Memory T Cells Associated with Various Cancers.Semantic proximity Read ↗

Tumor-resident memory T cells as a biomarker of the response to cancer immunotherapySemantic proximity Read ↗

Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer.Semantic proximity Read ↗

Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancerSemantic proximity Read ↗

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.Semantic proximity Read ↗

Tissue-resident memory CD8+ T cells in cancer immunology and immunotherapy.Semantic proximity Read ↗

Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector ResponsesSemantic proximity Read ↗

The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.