Article
Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer.
Cancer immunology research - 1 Dec 2020
Horeweg Nanda, de Bruyn Marco, Nout Remi A, Stelloo Ellen, Kedziersza Katarzyna, León-Castillo Alicia, Plat Annechien, Mertz Kirsten D, Osse Michelle, Jürgenliemk-Schulz Ina M, Lutgens Ludy C H W, Jobsen Jan J, van der Steen-Banasik Elzbieta M, Smit Vincent T, Creutzberg Carien L, Bosse Tjalling, Nijman Hans W, Koelzer Viktor H, Church David N
Abstract excerpt
Optimum risk stratification in early-stage endometrial cancer combines clinicopathologic factors and the molecular endometrial cancer classification defined by The Cancer Genome Atlas (TCGA). It is unclear whether analysis of intratumoral immune infiltrate improves this. We developed a machine-learning, image-based algorithm to quantify density of CD8+ and CD103+ immune cells in tumor epithelium and stroma in 695...
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