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Article

Transcriptional Activity and Stability of CD39+CD103+CD8+ T Cells in Human High-Grade Endometrial Cancer.

International journal of molecular sciences - 27 May 2020

Workel Hagma H, van Rooij Nienke, Plat Annechien, Spierings Diana C J, Fehrmann Rudolf S N, Nijman Hans W, de Bruyn Marco

Abstract excerpt

Tumor-infiltrating CD8+ T cells (TIL) are of the utmost importance in anti-tumor immunity. CD103 defines tumor-resident memory T cells (TRM cells) associated with improved survival and response to immune checkpoint blockade (ICB) across human tumors. Co-expression of CD39 and CD103 marks tumor-specific TRM with enhanced cytolytic potential, suggesting that CD39+CD103+ TRM could be a suitable biomarker for...

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Identifiers

PMID: 32471032
DOI: 10.3390/ijms21113770
PMCID: PMC7312498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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