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Nanofluidic Digital PCR and Extended Genotyping of RAS and BRAF for Improved Selection of Metastatic Colorectal Cancer Patients for Anti-EGFR Therapies.

Molecular cancer therapeutics - 1 May 2016

Azuara Daniel, Santos Cristina, Lopez-Doriga Adriana, Grasselli Julieta, Nadal Marga, Sanjuan Xavier, Marin Fátima, Vidal Joana, Montal Robert, Moreno Victor, Bellosillo Beatriz, Argiles Guillem, Elez Elena, Dienstmann Rodrigo, Montagut Clara, Tabernero Josep, Capellá Gabriel, Salazar Ramon

Abstract excerpt

The clinical significance of low-frequent RAS pathway-mutated alleles and the optimal sensitivity cutoff value in the prediction of response to anti-EGFR therapy in metastatic colorectal cancer (mCRC) patients remains controversial. We aimed to evaluate the added value of genotyping an extended RAS panel using a robust nanofluidic digital PCR (dPCR) approach. A panel of 34 hotspots, including RAS (KRAS and NRAS...

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Identifiers

PMID: 27037411
DOI: 10.1158/1535-7163.MCT-15-0820

Genes

BRAF
EGFR
KRAS
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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