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Article

Rare RAS Mutations in Metastatic Colorectal Cancer Detected During Routine RAS Genotyping Using Next Generation Sequencing.

Targeted oncology - 1 Jun 2016

Harlé Alexandre, Filhine-Tresarrieu Pierre, Husson Marie, Boidot Romain, Rouyer Marie, Dubois Cindy, Leroux Agnès, Merlin Jean-Louis

Abstract excerpt

BACKGROUND: Overall survival of metastatic colorectal cancer (mCRC) patients has been improved with the addition of targeted therapy such as anti-epithelial growth factor receptor monoclonal antibodies (anti-EGFR mAbs) to standard chemotherapy. Retrospective studies and randomized trials showed that the presence of RAS mutations was linked to the absence of clinical response to anti-EGFR mAbs. Patients harboring...

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Source

Identifiers

PMID: 26661077
DOI: 10.1007/s11523-015-0404-7

Genes

EGFR
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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