Article
Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.
PloS one - 1 Jan 2020
Franczak Claire, Witz Andréa, Geoffroy Karen, Demange Jessica, Rouyer Marie, Husson Marie, Massard Vincent, Gavoille Céline, Lambert Aurélien, Gilson Pauline, Gambier Nicolas, Scala-Bertola Julien, Merlin Jean-Louis, Harlé Alexandre
Abstract excerpt
BACKGROUND: Cell-free DNA detection is becoming a surrogate assay for tumor genotyping. Biological fluids often content a very low amount of cell-free tumor DNA and assays able to detect very low allele frequency mutant with a few quantities of DNA are required. We evaluated the ability of the fully-automated molecular diagnostics platform Idylla for the detection of KRAS, NRAS and BRAF hotspot mutations in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.