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Genetically predicted 17beta-estradiol, cognitive function and depressive symptoms in women: A Mendelian randomization in the Guangzhou Biobank Cohort Study.

Preventive medicine - 1 Jul 2016

Au Yeung Shiu Lun, Jiang Chaoqiang, Cheng Kar Keung, Zhang Weisen, Lam Tai Hing, Leung Gabriel Matthew, Schooling C Mary

Abstract excerpt

OBJECTIVE: The role of estrogen in cognitive function and depressive symptoms is controversial due to discrepancies between results from randomized controlled trials (RCT) and observational studies. Mendelian randomization analysis may provide further insights concerning the role of estrogen in these outcomes as it assesses the effect of lifelong endogenous exposure but is less vulnerable to confounding than...

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PMID: 27036929
DOI: 10.1016/j.ypmed.2016.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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