Article
Vitamin D and cognitive function: A Mendelian randomisation study.
Scientific reports - 16 Oct 2017
Maddock Jane, Zhou Ang, Cavadino Alana, Kuźma Elżbieta, Bao Yanchun, Smart Melissa C, Saum Kai-Uwe, Schöttker Ben, Engmann Jorgen, Kjærgaard Marie, Karhunen Ville, Zhan Yiqiang, Lehtimäki Terho, Rovio Suvi P, Byberg Liisa, Lahti Jari, Marques-Vidal Pedro, Sen Abhijit, Perna Laura, Schirmer Henrik, Singh-Manoux Archana, Auvinen Juha, Hutri-Kähönen Nina, Kähönen Mika, Kilander Lena, Räikkönen Katri, Melhus Håkan, Ingelsson Erik, Guessous Idris, Petrovic Katja E, Schmidt Helena, Schmidt Reinhold, Vollenweider Peter, Lind Lars, Eriksson Johan G, Michaëlsson Karl, Raitakari Olli T, Hägg Sara, Pedersen Nancy L, Herzig Karl-Heinz, Järvelin Marjo-Riitta, Veijola Juha, Kivimaki Mika, Jorde Rolf, Brenner Hermann, Kumari Meena, Power Chris, Llewellyn David J, Hyppönen Elina
Abstract excerpt
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive...
Read the complete abstract on PubMed