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Article

A Mendelian randomization study of testosterone and cognition in men.

Scientific reports - 11 Feb 2016

Zhao Jie V, Lam Tai Hing, Jiang Chaoqiang, Cherny Stacey S, Liu Bin, Cheng Kar Keung, Zhang Weisen, Leung Gabriel M, Schooling C Mary

Abstract excerpt

Testosterone replacement for older men is increasingly common, with some observations suggesting a protective effect on cognitive function. We examined the association of endogenous testosterone with cognitive function among older men in a Mendelian randomization study using a separate-sample instrumental variable (SSIV) analysis estimator to minimize confounding and reverse causality. A genetic score predicting...

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Identifiers

PMID: 26864717
DOI: 10.1038/srep21306
PMCID: PMC4749999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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