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Exploring the Impacts of Age at Menarche on Cognitive Aging in Late Adulthood: Evidence from a Mendelian Randomization Study on the Taiwanese Population.

Dementia and geriatric cognitive disorders - 1 Jan 2024

Fang Chen-Wen, Yang Cheng-Yi, Chau Hephaes Chuen, Tsai Meng-Che

Abstract excerpt

INTRODUCTION: The potential influence of age at menarche (AM) on cognitive aging remains inadequate, partly because of the difficulties presented by multiple confounders. To address this issue, Mendelian randomization (MR) analysis was used to explore the causal impacts of AM on cognitive aging. METHODS: Using the publicly accessible Taiwan Biobank, we identified single nucleotide polymorphisms (SNPs)...

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PMID: 38560983
DOI: 10.1159/000538620

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