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Article

Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium.

Antimicrobial agents and chemotherapy - 1 Nov 2012

Humphries Romney M, Kelesidis Theodoros, Tewhey Ryan, Rose Warren E, Schork Nicholas, Nizet Victor, Sakoulas George

Abstract excerpt

Whole-genome sequencing and cell membrane studies of three clonal Enterococcus faecium strains with daptomycin MICs of 4, 32, and 192 μg/ml were performed, revealing nonsynonymous single nucleotide variants in eight open reading frames, including those predicted to encode a phosphoenolpyruvate-de...

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Identifiers

PMID: 22948885
DOI: 10.1128/AAC.01318-12
PMCID: PMC3486580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22948885-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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