Molecular alterations in the TCR signaling pathway in patients with aplastic anemia.

doi:10.1186/s13045-016-0261-6

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Article

Molecular alterations in the TCR signaling pathway in patients with aplastic anemia.

Journal of hematology & oncology - 31 Mar 2016

Li Bo, Guo Lixing, Zhang Yuping, Xiao Yankai, Wu Mingjuan, Zhou Lingling, Chen Shaohua, Yang Lijian, Lu Xiang, Li Yangqiu

Abstract excerpt

BACKGROUND: A previous study has demonstrated a significantly increased CD3ζ gene expression level in aplastic anemia (AA). However, the mechanism underlying the upregulated CD3ζ mRNA expression level and that of T cell activation signaling molecules in AA patients remains unclear. Thus, we investigated the expression levels of the CD3ζ, CD28, CTLA-4, and Cbl-b genes, the SNP rs231775 in the CTLA-4 gene, and the...

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PMID: 27036622
DOI: 10.1186/s13045-016-0261-6
PMCID: PMC4818392

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