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Article

Somatic mutations in CSK disrupt immune regulation in a Chinese aplastic anemia cohort.

Communications biology - 11 May 2026

He Weirong, Li Feifei, Wu Liangliang, Sun Xiaoyue, Zhang Yuping, Mo Wenjian, Chen Xiaowei, Cheng Zihan, Shen Xiaopeng, Zhang Wenqing, Huang Zhibin, Wang Shunqing

Abstract excerpt

Aplastic anemia (AA) is a rare hematological disorder characterized by the failure of bone marrow hematopoiesis. Although somatic mutations are known to play pivotal roles in the pathogenesis and clinical progression of AA, their molecular characteristics in Chinese AA patients remain poorly characterized. In this study, we perform whole-exome sequencing on 126 Chinese AA patients to delineate the somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42115285
DOI: 10.1038/s42003-026-10220-0
PMCID: PMC13385770

Genes

CSK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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