Article
Assessment of the genetic variance of late-onset Alzheimer's disease.
Neurobiology of aging - 1 May 2016
Ridge Perry G, Hoyt Kaitlyn B, Boehme Kevin, Mukherjee Shubhabrata, Crane Paul K, Haines Jonathan L, Mayeux Richard, Farrer Lindsay A, Pericak-Vance Margaret A, Schellenberg Gerard D, Kauwe John S K
Abstract excerpt
Alzheimer's disease (AD) is a complex genetic disorder with no effective treatments. More than 20 common markers have been identified, which are associated with AD. Recently, several rare variants have been identified in Amyloid Precursor Protein (APP), Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) and Unc-5 Netrin Receptor C (UNC5C) that affect risk for AD. Despite the many successes, the genetic...
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