Article
The genetic landscape of Alzheimer disease: clinical implications and perspectives.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2016
Van Cauwenberghe Caroline, Van Broeckhoven Christine, Sleegers Kristel
Abstract excerpt
The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1, and Presenilin 2 as a cause of autosomal dominant AD, the identification of the ɛ4 allele of Apolipoprotein E as a strong genetic risk factor for both early-onset and late-onset AD, and...
Topics
- Alleles
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Apolipoproteins E
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mutation
- Precision Medicine
- Presenilin-1