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Article

FOXA1 defines cancer cell specificity.

Science advances - 1 Mar 2016

Zhang Gaihua, Zhao Yongbing, Liu Yi, Kao Li-Pin, Wang Xiao, Skerry Benjamin, Li Zhaoyu

Abstract excerpt

A transcription factor functions differentially and/or identically in multiple cell types. However, the mechanism for cell-specific regulation of a transcription factor remains to be elucidated. We address how a single transcription factor, forkhead box protein A1 (FOXA1), forms cell-specific genomic signatures and differentially regulates gene expression in four human cancer cell lines (HepG2, LNCaP, MCF7, and...

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Share to Epigenesis, Genetic
Share to Chromatin Immunoprecipitation
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Nuclear Factor 3-alpha

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasms

Share to Organ Specificity

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27034986
DOI: 10.1126/sciadv.1501473
PMCID: PMC4803482

Genes

FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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