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Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including <i>CD274</i> /PD-L1

2020-09-11

Abstract excerpt

Forkhead Box A1 (FOXA1) is a pioneer transcription factor critical in epigenetic regulation of chromatin and cell fate determination. Reduced FOXA1 expression is an independent predictor of poor overall survival in bladder cancer patients. However, the impact of FOXA1 loss on chromatin epigenetics in bladder cancer is unknown. Therefore, we determined the impact of FOXA1 knock out (KO) on epigenetic modification...

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Literature Corpus work
15123573-493e-5dc4-9e2e-ab11d444f467
DOI
10.1101/2020.09.11.294041
Open publication

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Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including <i>CD274</i> /PD-L1DOI 10.1101/2020.09.11.294041
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