Article
KIT oncogene inhibition drives intratumoral macrophage M2 polarization.
The Journal of experimental medicine - 16 Dec 2013
Cavnar Michael J, Zeng Shan, Kim Teresa S, Sorenson Eric C, Ocuin Lee M, Balachandran Vinod P, Seifert Adrian M, Greer Jonathan B, Popow Rachel, Crawley Megan H, Cohen Noah A, Green Benjamin L, Rossi Ferdinand, Besmer Peter, Antonescu Cristina R, DeMatteo Ronald P
Abstract excerpt
Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulation of TAMs is under intense investigation because they are thought to be nearly always of the M2 subtype, which supports tumor growth. Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and typically results from an activating mutation in the KIT oncogene. Using a spontaneous mouse model of GIST...
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