Article
Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine.
PLoS pathogens - 1 Mar 2016
Sanders Barbara P, de Los Rios Oakes Isabel, van Hoek Vladimir, Bockstal Viki, Kamphuis Tobias, Uil Taco G, Song Yutong, Cooper Gillian, Crawt Laura E, Martín Javier, Zahn Roland, Lewis John, Wimmer Eckard, Custers Jerome H H V, Schuitemaker Hanneke, Cello Jeronimo, Edo-Matas Diana
Abstract excerpt
The poliovirus vaccine field is moving towards novel vaccination strategies. Withdrawal of the Oral Poliovirus Vaccine and implementation of the conventional Inactivated Poliovirus Vaccine (cIPV) is imminent. Moreover, replacement of the virulent poliovirus strains currently used for cIPV with at...
Topics
- Animals
- Cold Temperature
- Hot Temperature
- Mice, Transgenic
- Mutation
- Phenotype
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Inactivated
- Poliovirus Vaccine, Oral