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Article

Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Mar 2013

Kim Woojin S, Li Hongyun, Ruberu Kalani, Chan Sharon, Elliott David A, Low Jac Kee, Cheng David, Karl Tim, Garner Brett

Abstract excerpt

ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons. ABCA7 promotes efflux of lipids from cells to apolipoproteins and can also regulate phagocytosis and modulate processing of amyloid precursor protein (APP) to generate the Alzheimer's disease (AD) amyloid-β (Aβ) peptide. Genome-wide association studies have indicated that ABCA7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23467355
DOI: 10.1523/JNEUROSCI.4165-12.2013
PMCID: PMC6704948

Genes

ABCA7
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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