Article
An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Mar 2016
Bjorness Theresa E, Dale Nicholas, Mettlach Gabriel, Sonneborn Alex, Sahin Bogachan, Fienberg Allen A, Yanagisawa Masashi, Bibb James A, Greene Robert W
Abstract excerpt
Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves during subsequent sleep. Here we demonstrate that mice deficient for glial adenosine kinase (AdK), the primary metabolizing enzyme for adenosine (Ado), exhibit enhanced expression of this homeostatic drive by three independent measures: (1) increased rebound of slow-wave activity; (2) increased...
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