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Article

2-(4-Hydroxyphenyl)benzothiazole dicarboxylate ester TACN chelators for 64Cu PET imaging in Alzheimer's disease.

Dalton transactions (Cambridge, England : 2003) - 17 Jan 2022

Wang Yujue, Huynh Truc T, Bandara Nilantha, Cho Hong-Jun, Rogers Buck E, Mirica Liviu M

Abstract excerpt

Herein we report a new series of bifunctional chelators (BFCs) with high affinity for amyloid β aggregates, strong binding affinity towards Cu(II), and favorable lipophilicity for potential blood-brain barrier (BBB) penetration. The alkyl carboxylate ester pendant arms show high binding affinity towards Cu(II). The BFCs form stable 64Cu-radiolabeled complexes and exhibit favorable partition coefficient (log D)...

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Identifiers

PMID: 34951428
DOI: 10.1039/d1dt02767k
PMCID: PMC8969080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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