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Article

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.

Nature communications - 31 Mar 2016

Joshi Peter K, Fischer Krista, Schraut Katharina E, Campbell Harry, Esko Tõnu, Wilson James F

Abstract excerpt

Lifespan is a trait of enormous personal interest. Research into the biological basis of human lifespan, however, is hampered by the long time to death. Using a novel approach of regressing (272,081) parental lifespans beyond age 40 years on participant genotype in a new large data set (UK Biobank), we here show that common variants near the apolipoprotein E and nicotinic acetylcholine receptor subunit alpha 5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27029810
DOI: 10.1038/ncomms11174
PMCID: PMC5438072

Genes

APOE
CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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