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Article

Meta-analysis for Discovering Rare-Variant Associations: Statistical Methods and Software Programs.

American journal of human genetics - 2 Jul 2015

Tang Zheng-Zheng, Lin Dan-Yu

Abstract excerpt

There is heightened interest in using next-generation sequencing technologies to identify rare variants that influence complex human diseases and traits. Meta-analysis is essential to this endeavor because large sample sizes are required for detecting associations with rare variants. In this article, we provide a comprehensive overview of statistical methods for meta-analysis of sequencing studies for discovering...

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Identifiers

PMID: 26094574
DOI: 10.1016/j.ajhg.2015.05.001
PMCID: PMC4571037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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