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Meta-analysis methods for genome-wide association studies and beyond.

Nature reviews. Genetics - 1 Jun 2013

Evangelou Evangelos, Ioannidis John P A

Abstract excerpt

Meta-analysis of genome-wide association studies (GWASs) has become a popular method for discovering genetic risk variants. Here, we overview both widely applied and newer statistical methods for GWAS meta-analysis, including issues of interpretation and assessment of sources of heterogeneity. We also discuss extensions of these meta-analysis methods to complex data. Where possible, we provide guidelines for...

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Bayes Theorem
Data Interpretation, Statistical
Genetic Heterogeneity
Genome-Wide Association Study
Meta-Analysis as Topic

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PMID: 23657481
DOI: 10.1038/nrg3472

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