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Article

Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2003

Matsumoto Mitsuyuki, Weickert Cynthia Shannon, Beltaifa Senda, Kolachana Bhaskar, Chen Jingshan, Hyde Thomas M, Herman Mary M, Weinberger Daniel R, Kleinman Joel E

Abstract excerpt

Human prefrontal cortical neurons express catechol O-methyltransferase (COMT), an enzyme that inactivates the neurotransmitter dopamine. A functional polymorphism of COMT, Val(108/158) Met, affects prefrontal function, and the high-activity Val allele has been reported to be a genetic risk factor for schizophrenia. We used in situ hybridization histochemistry to measure mRNA levels of COMT in the dorsolateral...

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Source

Identifiers

PMID: 12799619
DOI: 10.1038/sj.npp.1300218

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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