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Article

Structural locus of the pH gate in the Kir1.1 inward rectifier channel.

Biophysical journal - 1 Apr 2005

Sackin Henry, Nanazashvili Mikheil, Palmer Lawrence G, Krambis M, Walters D E

Abstract excerpt

The closed-state crystal structure of prokaryotic inward rectifier, KirBac1.1, has implicated four inner helical phenylalanines near the cytoplasmic side as a possible locus of the channel gate. In the present study, we investigate whether this structural feature corresponds to the physiological pH gate of the renal inward rectifier, Kir1.1 (ROMK, KCNJ1). Kir1.1 is endogenous to the mammalian renal collecting...

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Source

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Identifiers

PMID: 15653740
DOI: 10.1529/biophysj.104.051474
PMCID: PMC1305356

Genes

KCNJ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Structural locus of the pH gate in the Kir1.1 inward rectifier channel.PMID 15653740Read ↗

pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.Semantic proximity Read ↗

Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.Semantic proximity Read ↗

Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels.Semantic proximity Read ↗

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Non-basic amino acids in the ROMK1 channels via an appropriate distance modulate PIP2 regulated pHi-gating.Semantic proximity Read ↗

Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.Semantic proximity Read ↗

KirBac1.1: it's an inward rectifying potassium channel.Semantic proximity Read ↗

Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.Semantic proximity Read ↗

The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating.Semantic proximity Read ↗

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A conserved cytoplasmic region of ROMK modulates pH sensitivity, conductance, and gating.Semantic proximity Read ↗

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