Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.

PLoS genetics - 1 Mar 2016

Peters James E, Lyons Paul A, Lee James C, Richard Arianne C, Fortune Mary D, Newcombe Paul J, Richardson Sylvia, Smith Kenneth G C

Abstract excerpt

Genome-wide association studies (GWAS) have transformed our understanding of the genetics of complex traits such as autoimmune diseases, but how risk variants contribute to pathogenesis remains largely unknown. Identifying genetic variants that affect gene expression (expression quantitative trait loci, or eQTLs) is crucial to addressing this. eQTLs vary between tissues and following in vitro cellular activation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Inflammatory Bowel Diseases

Share to Monocytes

Share to Neutrophils

Share to Quantitative Trait Loci

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 27015630
DOI: 10.1371/journal.pgen.1005908
PMCID: PMC4807835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.PMID 27015630Read ↗

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.Semantic proximity Read ↗

Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease.Semantic proximity Read ↗

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatmentSemantic proximity Read ↗

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activationSemantic proximity Read ↗

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associationsSemantic proximity Read ↗

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.Semantic proximity Read ↗

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.Semantic proximity Read ↗

Single-cell genetics identifies cell-type-specific effector genes across complex traits and diseasesSemantic proximity Read ↗

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.Semantic proximity Read ↗

Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.Semantic proximity Read ↗

Integrative multiomics analysis highlights immune-cell regulatory mechanisms and shared genetic architecture for 14 immune-associated diseases and cancer outcomes.Semantic proximity Read ↗

Immunogenomic approaches to understand the function of immune disease variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.