Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers.

doi:10.18632/oncotarget.8272

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Article

Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers.

Oncotarget - 3 May 2016

Benitez-Buelga Carlos, Vaclová Tereza, Ferreira Sofia, Urioste Miguel, Inglada-Perez Lucia, Soberón Nora, Blasco Maria A, Osorio Ana, Benitez Javier

Abstract excerpt

We have recently shown that rs2304277 variant in the OGG1 glycosidase gene of the Base Excision Repair pathway can increase ovarian cancer risk in BRCA1 mutation carriers. In the present study, we aimed to explore the role of this genetic variant on different genome instability hallmarks to explain its association with cancer risk.We have evaluated the effect of this polymorphism on OGG1 transcriptional...

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Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Glycosylases

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Predisposition to Disease

Share to Ovarian Neoplasms

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 27015555
DOI: 10.18632/oncotarget.8272
PMCID: PMC5041946

Genes

BRCA1
OGG1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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