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Article

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

22 Mar 2019

Abstract excerpt

Abstract The BCL6 Corepressor (BCOR) is a component of a variant Polycomb repressive complex 1 (PRC1) that is essential for normal development. Recurrent mutations in the BCOR gene have been identified in acute myeloid leukaemia and myelodysplastic syndrome among other cancers; however, its function remains poorly understood. Here we examine the role of BCOR in haematopoiesis in vivo using a conditional mouse...

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PMID: 30902969
DOI: 10.1038/s41467-019-09250-6

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