Article
An essential gene mutagenesis screen across the highly conserved piebald deletion region of mouse chromosome 14.
Genesis (New York, N.Y. : 2000) - 1 Jun 2009
Hagarman James A, O'Brien Timothy P
Abstract excerpt
The piebald deletion complex is a set of overlapping chromosomal deficiencies on distal mouse chromosome 14. We surveyed the functional genetic content of the piebald deletion region in an essential gene mutagenesis screen of 952 genomes to recover seven lethal mutants. The ENU-induced mutations were mapped to define genetic intervals using the piebald deletion panel. Lethal mutations included loci required for...
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