Article
Modeling Rare Human Disorders in Mice: The Finnish Disease Heritage.
Cells - 13 Nov 2021
Zárybnický Tomáš, Heikkinen Anne, Kangas Salla M, Karikoski Marika, Martínez-Nieto Guillermo Antonio, Salo Miia H, Uusimaa Johanna, Vuolteenaho Reetta, Hinttala Reetta, Sipilä Petra, Kuure Satu
Abstract excerpt
The modification of genes in animal models has evidently and comprehensively improved our knowledge on proteins and signaling pathways in human physiology and pathology. In this review, we discuss almost 40 monogenic rare diseases that are enriched in the Finnish population and defined as the Finnish disease heritage (FDH). We will highlight how gene-modified mouse models have greatly facilitated the...
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