Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice.

doi:10.1186/s12929-017-0365-5

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Article

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice.

Journal of biomedical science - 17 Aug 2017

Kumar Sudhir, Rathkolb Birgit, Sabrautzki Sibylle, Krebs Stefan, Kemter Elisabeth, Becker Lore, Beckers Johannes, Bekeredjian Raffi, Brommage Robert, Calzada-Wack Julia, Garrett Lillian, Hölter Sabine M, Horsch Marion, Klingenspor Martin, Klopstock Thomas, Moreth Kristin, Neff Frauke, Rozman Jan, Fuchs Helmut, Gailus-Durner Valérie, Hrabe de Angelis Martin, Wolf Eckhard, Aigner Bernhard

Abstract excerpt

BACKGROUND: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further analyzed. METHODS: Analysis of the causative mutation as well as the standardized, systemic...

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PMID: 28818080
DOI: 10.1186/s12929-017-0365-5
PMCID: PMC5559776

Genes

KCTD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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