Article
Mouse phenotyping.
Methods (San Diego, Calif.) - 1 Feb 2011
Fuchs Helmut, Gailus-Durner Valérie, Adler Thure, Aguilar-Pimentel Juan Antonio, Becker Lore, Calzada-Wack Julia, Da Silva-Buttkus Patricia, Neff Frauke, Götz Alexander, Hans Wolfgang, Hölter Sabine M, Horsch Marion, Kastenmüller Gabi, Kemter Elisabeth, Lengger Christoph, Maier Holger, Matloka Mikolaj, Möller Gabriele, Naton Beatrix, Prehn Cornelia, Puk Oliver, Rácz Ildikó, Rathkolb Birgit, Römisch-Margl Werner, Rozman Jan, Wang-Sattler Rui, Schrewe Anja, Stöger Claudia, Tost Monica, Adamski Jerzy, Aigner Bernhard, Beckers Johannes, Behrendt Heidrun, Busch Dirk H, Esposito Irene, Graw Jochen, Illig Thomas, Ivandic Boris, Klingenspor Martin, Klopstock Thomas, Kremmer Elisabeth, Mempel Martin, Neschen Susanne, Ollert Markus, Schulz Holger, Suhre Karsten, Wolf Eckhard, Wurst Wolfgang, Zimmer Andreas, Hrabě de Angelis Martin
Abstract excerpt
Model organisms like the mouse are important tools to learn more about gene function in man. Within the last 20 years many mutant mouse lines have been generated by different methods such as ENU mutagenesis, constitutive and conditional knock-out approaches, knock-down, introduction of human genes, and knock-in techniques, thus creating models which mimic human conditions. Due to pleiotropic effects, one gene may...
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