Article
Archaeal MutS5 tightly binds to Holliday junction similarly to eukaryotic MutSγ.
The FEBS journal - 1 Oct 2017
Ohshita Koki, Fukui Kenji, Sato Mizuki, Morisawa Takashi, Hakumai Yuichi, Morono Yuki, Inagaki Fumio, Yano Takato, Ashiuchi Makoto, Wakamatsu Taisuke
Abstract excerpt
Archaeal DNA recombination mechanism and the related proteins are similar to those in eukaryotes. However, no functional homolog of eukaryotic MutSγ, which recognizes Holliday junction to promote homologous recombination, has been identified in archaea. Hence, the whole molecular mechanism of archaeal homologous recombination has not yet been revealed. In this study, to identify the archaeal functional homolog of...
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