Article
The clinical relevance and prognostic significance of microsomal epoxide hydrolase gene polymorphisms and their susceptibility to acquired aplastic anemia: an Egyptian study.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jul 2016
Makhlouf Manal Mohamed, Magdy Rania Ismail
Abstract excerpt
BACKGROUND: Microsomal epoxide hydrolase enzyme (mEPHX) is involved in xenobiotics detoxification. Two variants of mEPHX, Tyr113His and His139Arg, have been described. Both may lead to acquired aplastic anemia (AA). OBJECTIVES: Assessing mEPHX genetic polymorphisms and detecting their impact on susceptibility and prognosis in Egyptian AA patients. PARTICIPANTS AND METHODS: mEPHX 113 and 139 genotypes were...
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