Article
EPHX1 gene polymorphisms in alcohol dependence and their distribution among the Indian populations.
The American journal of drug and alcohol abuse - 1 Jan 2013
Bhaskar L V K S, Thangaraj K, Patel Minarbha, Shah Anish M, Gopal K, Saikrishna L, Tamang Rakesh, Singh Lalji, Rao V R
Abstract excerpt
BACKGROUND: The microsomal epoxide hydrolase is a phase II enzyme of the biotransformation. The human epoxide hydrolase 1 (EPHX1) gene lies in the chromosomal region 1q42.1 and exhibits polymorphism. Two single nucleotide polymorphisms (SNPs) have been described in the coding region of the EPHX1 gene that produces two protein variants. SUBJECTS AND METHODS: A total of 604 samples belonging to 13 Indian...
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