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Article

The Autoimmune Regulator Prevents Premature Reproductive Senescence in Female Mice1

6 Jan 2012

Abstract excerpt

Loss-of-function mutations in the autoimmune regulator (AIRE) gene are responsible for autoimmune polyglandular syndrome type 1 (APS-1), which commonly manifests as infertility in women. AIRE is a transcriptional regulator that promotes expression of tissue-restricted antigens in the thymus, including antigens specific to the ovary. Thymic expression of ovarian genes under AIRE's control may be critical for...

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PMID: 22219212
DOI: 10.1095/biolreprod.111.097501

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The Autoimmune Regulator Prevents Premature Reproductive Senescence in Female Mice1PMID 22219212Read ↗

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