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Article

Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2011

Rodriguez Karien J, Piechura Laura M, Masters Kristyn S

Abstract excerpt

Disruption of the extracellular matrix (ECM) is frequently found in calcific aortic valve disease (CAVD), yet the role of ECM components in valvular interstitial cell (VIC) function and dysfunction remains poorly understood. This study examines the contributions of exogenous and endogenous hyaluronic acid (HA), in both two-dimensional (2-D) and 3-D environments, in regulating the phenotype and calcification of...

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Identifiers

PMID: 20884350
DOI: 10.1016/j.matbio.2010.09.001
PMCID: PMC3021089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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